HPV Virus and Oral Cancer

[Todd Welch]

Actor Michael Douglas' recent revelation that he has stage IV oral cancer has highlighted the growing incidence of oral cancer, and experts say dentists can help stem the alarming increase of the disease by checking for it during routine examinations.

The actor's cancer includes a walnut-sized tumor at the base of his
tongue, and he will require radiation therapy, chemotherapy, and
surgery. Douglas says his doctors told him he has an 80% survival rate
if it hasn't spread to his lymph nodes.

While tobacco was the prime cause of oral cancer in the past, recent studies have attributed the steady increase of the disease to
the human papillomavirus (HPV). HPV are common viruses that cause
warts. There are approximately 130 versions of HPV but only nine cause
cancers, and the HPV16 version causes almost half of the oral cancers in the U.S., said Brian Hill, executive director of the Oral Cancer Foundation.

"Tobacco is no longer the only bad guy," he told DrBicuspid.com. “HPV16 is increasing in incidence as the causative etiology, and if it
continues on this trend line, it will replace tobacco as the primary
cause of oral cancers."

Dentists can play a key role in catching the disease in its early stages if they check for it during examinations. Most Americans have
never even heard of oral cancer, but it's not as rare or
uncommon as people would like to think it is. This is why an
opportunistic screening by the dental community is so important.

Hill, a nonsmoker, got the same diagnosis as Douglas in 1998 and underwent radiation therapy, chemotherapy, and surgery. Since Hill's
oral cancer had metastasized to both sides of his neck by the time it
was discovered, surgeons removed the right side of his neck to remove
the lymph nodes there. He has been cancer-free for 10 years and said
there are a lot of stage IV survivors out there.

Changing demographics

In the last decade, the demographics of oral cancer have changed dramatically, according to Hill and other experts, pointing to the sexual revolution and accompanying increase in the prevalence of oral
sex. Today almost half of those diagnosed with the disease are younger
than 50 years old -- with some as young as 20, according to Hill -- and
they are usually nonsmokers. According to the American Cancer Society,
oral cancer occurs almost as frequently as leukemia and claims more
lives than melanoma or cervical cancer. The incidence in oral cancer
patients younger than age 40 has increased nearly fivefold, with many
patients with no known risk factors, according to the ADA.

"Social and sexual behaviors have changed," Hill said. "Oral sex is more common. The virus is spreading, especially among young people because sexual contact is more common, and this virus is not only ubiquitous in our society, but the mechanism of transfer is very simple."

Until 2000, scientists were unsure if HPV caused oral cancer, Hill said, but definitive research in 2000 revealed it as a distinct etiology for the disease, and more recent studies have supported this finding.

The disease is dangerous because often there are no symptoms in the early stages that a person might notice. "It's a very insidious disease," Hill explained. He recalled that it was not until a lymph node became swollen that Hill realized something was wrong. Even then, it was not painful, he said. Typically there are no physical signs of oral cancer. But an alert dentist will notice subtle signs and symptoms of oral cancer in a simple three to five minute visual and tactile exam, Hill noted.
"There will be things he'll pick up on, and that's why we're urging that the dental community to become more involved in oral cancer screening," he said. Approximately 36,000 new cases of oral cancer are diagnosed each year
in the U.S., according to the ADA, and some 25% of those people will die of the disease. Only 57% of all diagnosed oral cancer patients will be alive five years after their diagnosis, Hill said. Approximately 100 people in the U.S. will be diagnosed with oral cancer every day, he added, and one person will die every hour from it.

And unfortunately, celebrities with cancer helps bring about much needed public awareness about the disease, said Hill, noting that, in addition to Michael Douglas, such luminaries as Sigmund Freud and Ulysses S. Grant have been among its victims.

"When somebody famous gets the disease, it finally gets the world's attention," he noted.

For more information contact Dr. Todd Welch at www.wtnperioblog.com

[Cary Feuerman, DMD]

Todd,
Thanks for sharing this important information! Well done.